Targeted Delivery of FLT-Morpholino Using Cyclic RGD Peptide
نویسندگان
چکیده
منابع مشابه
Targeted Delivery of FLT-Morpholino Using Cyclic RGD Peptide
PURPOSE We previously showed that intravitreal injection of the sFLT morpholino-oligomer (FLT-MO) suppresses laser-induced choroidal neovascularization (CNV) in mice by decreasing the membrane bound form of Flt-1 while increasing the soluble form of Flt-1 via alternative splicing shift. In this study, we examined whether cyclic RGD peptide (cRGD) can promote morpholino-oligomer accumulation in ...
متن کاملCyclic RGD-Containing Peptide Prevents Neointima Formation
Background RGD-containing peptides are able to prevent binding of ligands to certain integrins such as a!IIb3 (glycoprotein Ilb/llla) and C4a33 and as such are inhibitors for platelet aggregation and smooth muscle cell migration, both of which are involved in neointima formation. Methods and Results Hamster carotid arteries were damaged, and neointima formation was determined at different time ...
متن کاملCyclic RGD peptide-modified liposomal drug delivery system for targeted oral apatinib administration: enhanced cellular uptake and improved therapeutic effects
Apatinib is an oral tyrosine kinase inhibitor, which selectively targets vascular endothelial growth factor receptor 2 and has the potential to treat many tumors therapeutically. Cyclic arginylglycylaspartic acid (cRGD)- and polyethylene glycol (PEG)-modified liposomes (cRGD-Lipo-PEG) were constructed to act as a targeted delivery system for the delivery of apatinib to the human colonic cancer ...
متن کاملPeptide Nanoparticle Delivery of Charge-Neutral Splice-Switching Morpholino Oligonucleotides
Oligonucleotide analogs have provided novel therapeutics targeting various disorders. However, their poor cellular uptake remains a major obstacle for their clinical development. Negatively charged oligonucleotides, such as 2'-O-Methyl RNA and locked nucleic acids have in recent years been delivered successfully into cells through complex formation with cationic polymers, peptides, liposomes, o...
متن کاملA new cyclic RGD peptide dimer for integrin αvβ3 imaging.
OBJECTIVE To design a new Arg-Gly-Asp (RGD) peptide that can specifically bind integrin αvβ3 and evaluate the possibility of using 131I-labeled peptide for imaging αvβ3-positive tumors. MATERIALS AND METHODS The structure of the RGD monomer was selected using V-life software. Based on the RGD monomer, a dimer of cyclic RGD [c(RGD)2] linked by Tyr-(D)Ser-Lys-(D)Ser-Ser with a Gly-Gly-(D)Ala-Gl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Translational Vision Science & Technology
سال: 2017
ISSN: 2164-2591
DOI: 10.1167/tvst.6.3.9